Scholarship on anti-slavery in the American South has traditionally focused on a handful of Southern-born figures, such as Sarah and Angelina Grimké, Cassius Clay, and John G. Fee. This is unsurprising, as prominent campaigners against the cruel system of slavery these individuals left strong historical footprints. For those less prominent opponents of slavery, often those who remained in the South, there are less available records on their activity, making it difficult for historians to detail their anti-slavery efforts. However, by collating the available information, no matter how small, on a large number of people, it becomes possible to paint a more nuanced image of anti-slavery in the South. Thus this paper details my analysis of one hundred Southern-born critics of slavery. Firstly, this paper will detail how I have compiled the personal data of these individuals in order to uncover any patterns that explain the development of their anti-slavery views. Secondly, I aim to demonstrate how using a large-scale analysis can enhance our understanding of how anti-slavery activity intersected with everyday life in the South, as opposed to the traditional scholarly focus on those prominent figures who campaigned on the big stages in cities such as Cincinnati and Boston.